14465 results for "PLOS+ONE+Pennsylvania+German+ACS+language+code+pdc+open+access+study"

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• Data Access Commitee, UCSF Pediatric Bithalamic Glioma Genome Project

  Dac EGAC00001001394

• Peter MacCallum Cancer Centre Research Data Access Committee

  Dac EGAC00001001404

• Cancer Sequencing Data Access Committee

  Dac EGAC00001001428

• Melanoma Spatial Heterogeneity Data Access Committee

  Dac EGAC00001001446

• Peter MacCallum Cancer Centre Research Data Access Committee

  Dac EGAC00001001505

• Tampere University Hospital Leukemia Reserach Data Access Committee

  Dac EGAC00001001551

• Mapping of mtDNA deletions and duplications Data Access Committe

  Dac EGAC00001001558

• Princess Margaret Head and Neck Cancer Data Access Committee

  Dac EGAC00001001647

• MD Anderson Lymphoma & Myeloma Data Access Committee

  Dac EGAC00001001685

• FIMM AML Single-Cell RNA-seq Data Access Committee

  Dac EGAC00001001709

• Biomedical Epigenomics Data Access Committee

  Dac EGAC00001001720

• Plasma cells in coeliac disease Data Access Committee

  Dac EGAC00001001753

• Low-grade Serous Ovarian Carcinoma Data Access Commitee

  Dac EGAC00001001763

• Breast Cancer Single-Cell Data Access Committee

  Dac EGAC00001001974

• VIB CCB Translational Genetics Data Access Committee

  Dac EGAC00001002006

• Multifocal ileal NETs WGS HFF7VCCXY folder Data Access Committee

  Dac EGAC00001002033

• IDIBAPS - Translational Research in Hepatic Oncology - Data Access Commitee

  Dac EGAC00001002069

• Varn Lab Data Access Committee

  Dac EGAC00001002118

• Molecular Characterization of HCC in Mongolia Data Access Commitee

  Dac EGAC00001002158

• MRC Institute of Genetics and Cancer Data Access Committee

  Dac EGAC00001002163

• Data access committee breast cancer whole genome sequencing HRD

  Dac EGAC00001002286

• Multifocal ileal NETs WGS HF3J5CCXY folder Data Access Committee

  Dac EGAC00001002321

• Multifocal ileal NETs WGS HF3FKCCXY folder Data Access Committee

  Dac EGAC00001002323

• Multifocal ileal NETs WGS HFG3FCCXY folder Data Access Committee

  Dac EGAC00001002324

• Multifocal ileal NETs WGS HF3NYCCXY folder Data Access Committee

  Dac EGAC00001002325

• Multifocal ileal NETs WGS HFFWLCCXY folder Data Access Committee

  Dac EGAC00001002326

• Data access Commitee for anti-PD1 in HCC data

  Dac EGAC00001002404

• Data Access Committee for Niigata-NIG collaborative work

  Dac EGAC00001002429

• Hematology Research Unit Helsinki Data Access Committee

  Dac EGAC00001002444

• Data Access Committee for Niigata-NIG collaborative work

  Dac EGAC00001002469

• B cells in Multiple Sclerosis Data Access Committee

  Dac EGAC00001002476

• TNBC (COH_TNBC_RNAseq) - Data Access Committee at The Jackson laboratory

  Dac EGAC00001002518

• TNBC (UW_OvCa_RNASeq) - Data Access Committee at The Jackson laboratory

  Dac EGAC00001002524

• TNBC (UW_OvCa_WGS) - Data Access Committee at The Jackson laboratory

  Dac EGAC00001002544

• NPC genome-wide human SNP array data access commitee

  Dac EGAC00001002560

• Single-cell Multiomics Clonal Hematopoiesis Team Data Access Committee

  Dac EGAC00001002735

• Institute of Pathology LMU Munich Data Access Commitee

  Dac EGAC00001002931

• Institute of Pathology LMU Munich Data Access Commitee

  Dac EGAC00001002932

• Multiple myeloma long-term survivor data access commitee

  Dac EGAC00001003078

• Hospital del Mar Research Insitute Data Access Comitte

  Dac EGAC00001002512

• Kyoto Prefectural University of Medicine Data Access Commitee

  Dac EGAC00001003411

• TNBC (COH_WGS) - Data Access Committee at The Jackson laboratory

  Dac EGAC00001002574

• Experimental Therapeutics in Lymphoid Malignancies Data Access Commitee

  Dac EGAC00001003210

• HPV Virome Consortium Data Access Committee

  Dac EGAC00001000141

• Data access commitee at the Molecular Exercise Physiology group

  Dac EGAC00001002606

• APOBEC Breast Data Access Committee

  Sarat Chandarlapaty chandars@mskcc.org

  Dac EGAC50000000554

• UQCCR/QCMG brain metastasis sequence analysis Data Access Committee

  Dac EGAC00001000180

• Data Access Committee for Triple Negative Breast Cancer dataset

  Dac EGAC00001003584

• Combination pembrolizumab and radiotherapy induces systemic anti-tumor immune responses in immunologically-cold non-small cell lung cancer

  The abscopal effects of radiation may sensitize immunologically “cold” tumors to immune checkpoint inhibition (ICI). We investigated the immunostimulatory effects of radiotherapy leveraging multi-omic analyses of serial tissue and blood biospecimens (n=293) from a phase 2 clinical trial of stereotactic body radiation therapy (SBRT) followed by pembrolizumab in metastatic non-small cell lung cancer (NSCLC; NCT02492568). Patients with immunologically-cold tumors (low tumor mutation burden, null PD-L1 expression, WNT-pathway mutated) in the SBRT arm had significantly longer progression-free survival compared to ICI alone (P<0.05). Induction of interferon-gamma, interferon-alpha, and antigen processing and presentation gene sets was significantly enriched post SBRT in non-irradiated tumor sites (FDR adjusted P<0.01). Significant on-therapy expansions of new and pre-existing TCR clones in both the tumor and blood compartments were noted in the SBRT arm (P<0.05). These findings support the systemic anti-tumor effects of immuno-radiotherapy and may open a therapeutic window of opportunity to overcome resistance to ICI.

  Dataset EGAD50000000404

• Genomic Answers for Kids (GA4K)

  Identification of complex genetic variants including defects in gene regulatory circuits and uncharacterized genes present challenges for rare disease diagnosis. In Genomic Answers for Kids program we apply the joint interpretation of patient genome sequence with genomic endophenotypes to expand the clinically actionable genome among pediatric cases of suspected genetic disease. Our objective is to examine the role of novel and under-interpreted sequence variation by combining complete DNA sequences, personal epigenetic variations and massively parallel functional screens. To achieve this we perform augmented whole genome sequence (WGS) interpretation including reanalysis of clinical exomes as well as generating WGS for patients with negative exome results all be subject to family-based semi-automated recall pipeline to discover missed diagnostic variation. We use linked-read and long-read sequencing technologies to focus on putative structural variants missed in short-read genome and exome analysis by the optimized integration of linked and long read technologies that also improve identification of transmission patterns of all variants, as well as resolving genomic regions resistant to standard alignment. We also include tissue DNA sequencing to investigate somatic mosaicism. To further assist with WGS interpretation for uncommon variation we capture snapshots of patient transcriptomes and epigenomes in individual cells using single-cell RNA (scRNA) and sc open chromatin (scATAC) as well as bulk whole genome bisulphite genome sequencing for methylome interpretation. Alternative splicing is functionally assessed in available patient tissues using RNA-seq, including full length cDNA sequences by IsoSeq (PacBio) methodology. Our overarching goal is an increase rate of diagnostic genomic findings up to two-fold among rare disease, resulting in the majority (>50%) of patient cases resolved by the integrated system developed in our program.

  Study phs002206