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• miRNA regulation of monocyte expressed inflammatory genes in patients with inflammatory bowel disease

  Study EGAS00001006157

• Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells

  Study EGAS00001007026

• Identification of IQCH as a calmodulin-associated protein required for sperm motility in humans

  Study EGAS00001007423

• Induction Failure in Childhood and Young Adult T-cell Acute Lymphoblastic Leukemia

  Study EGAS00001006411

• Accessibility Over Transposable Elements Reveals Genetic Determinants of Stemness Properties in Normal and Leukemic Hematopoiesis

  Study EGAS00001007191

• Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia

  Study EGAS00001005818

• Genome sequencing in monozygotic twins discordant for Mayer-Rokitansky-Küster-Hauser syndrome

  Study EGAS00001006371

• Möebius

  Exome sequencing in 3 Möbius patients

  Dataset EGAD00001001385

• Whole-genome sequencing of gastric cancer 81 samples in the Japanese population.

  Genomic DNA of 81 cases from Japanese gastric cancer was extracted from tumor and matched normal tissues, and libraries with an insert size of 350–550 bp were prepared. The libraries were sequenced on a HiSeq 2500 instrument (Illumina) with paired-end reads of 101 bp. The read data are stored as FASTQ formatted files.

  Dataset EGAD00001008610

• DAC for study: "Circulating tumour DNA abundance and potential utility in de novo metastatic prostate cancer"

  Dac EGAC00001001099

• Genomic stratification and liquid biopsy in a rare adrenocortical carcinoma (ACC) case, with dual lung metastases

  Dac EGAC00001001138

• Data Access Committee - cfDNA fragmentation and personalized sequencing reveal ctDNA in urine and plasma of glioma patients

  Dac EGAC00001001593

• Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women

  Dac EGAC00001002031

• Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

  Dataset EGAD00001001275

• RHD_FJ_HC24_Cases

  Rheumatic heart disease cases recruited in Fiji

  Dataset EGAD00010000961

• Concurrent germline and somatic pathogenic BAP1 variants in a patient with metastatic bladder cancer

  Study EGAS00001004055

• Characterization of stromal tumor-infiltrating lymphocytes and genomic alterations in metastatic lobular breast cancer

  Study EGAS00001004641

• Evaluating CRISPR-based Prime Editing for cancer modeling and CFTR repair in organoids

  Study EGAS00001005358

• Orthotopic murine Group 3 medulloblastoma in C57Bl/6 mice treated with saline, cyclophosphamide or gemcitabine

  Study EGAS00001005846

• Orthotopic murine Group 3 medulloblastoma in C57Bl/6 mice treated with sham or craniospinal irradiation

  Study EGAS00001005847

• NPY methylated ctDNA is a promising biomarker for treatment response monitoring in metastatic colorectal cancer

  Study EGAS00001006820

• DEREGULATION OF PRE-mRNA SPLICING IN MISMATCH REPAIR DEFICIENT COLORECTAL CANCER

  Study EGAS00001004863

• Characterization of UV DNA damage in B-cell precursor acute lymphoblastic leukemia

  Study EGAS00001008128

• Subgroup-specific gene expression profiles and mixed epistasis in chronic lymphocytic leukemia (HIPO, H005)

  Study EGAS00001006361

• RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

  Study EGAS00001006273

• DNA methylation using EPIC array in UK population study

  See www.understandingsociety.ac.uk

  Study EGAS00001002836

• Co-infection of fungi and bacteria in brain tissue from elderly persons and patients with Alzheimer's disease.

  Dac EGAC00001000797

• Wargo Group Data Access Committee for Neodjuvant Immune Checkpoint Blockade in High-Risk Resectable Melanoma

  Dac EGAC00001001008

• DAC - Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML

  Dac EGAC00001001461

• T cell receptors of pathogenic CD4 T cells isolated by using distinct phenotypic markers in celiac disease

  Dac EGAC00001002292

• Patient-derived tumor organoids for personalized medicine in a rare case of hepatocellular carcinoma with neuroendocrine differentiation.

  Dac EGAC00001002458

• Analysis of recent shared ancestry in a familial cohort identifies coding and noncoding autism spectrum disorder variants

  Dac EGAC00001002558

• EGAD00010000572

  Imputation-based meta-analysis of severe malaria in Gambia.

  Dataset EGAD00010000572

• RHD_NC_HC24_Cases

  Rheumatic heart disease cases recruited in New Caledonia

  Dataset EGAD00010000957

• Methylation_WB_RA

  Peripheral blood DNA methylome in adalimumab-treated patients with rheumatoid arthritis

  Dataset EGAD00010002610

• Short-read whole genome sequencing identifies causative variants in most individuals with previously unexplained aniridia

  Study EGAS00001006878

• Quality of Whole Genome Sequencing from Blood versus Saliva Derived DNA in Cardiac Patients

  Study EGAS00001004115

• : Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumours

  Study EGAS00001004239

• Evolutionary trajectories and clonal migration underlying tumor progression and lymph node metastasis in resectable lung cancer

  Study EGAS00001005242

• Transposable elements are co-opted as oncogenic regulatory elements by lineage-specific transcription factors in prostate cancer

  Study EGAS00001007188

• Epigenetic reprogramming shapes monocytes and heterologous T cell derived cytokine responses in BCG vaccination

  Study EGAS00001007498

• Homologous recombination DNA repair deficiency and activity of PARP inhibition in primary triple negative breast cancer

  Study EGAS00001004190

• Next Generation Sequencing Characterization of Hematopoietic Stem and Progenitors Cells in Human Systemic Lupus Eryhtematosus

  Study EGAS00001003679

• Oncolytic virotherapy mediated anti-tumor response in primary cutaneous B-cell lymphoma: a single-cell perspective

  Study EGAS00001004904

• Second hit rare genetic variants in families with seemingly GBA gene associated Parkinson’s disease

  Study EGAS00001004777

• Genetics causes of male infertility in 185 patient-parent trios from Netherlands and UK

  The dataset is composed by the raw and processed sequencing data generated from 185 Patients affected by azoospermia or severe oligozoospermia recruited from the Netherlands and the UK.

  Dataset EGAD00001007862

• DAC - Comparison of sequencing assays for sensitive detection of circulating tumour DNA in stage IA-IV breast cancer

  Dac EGAC00001002549

• Detection of ctDNA in Plasma of Patients with Clinically Localised Prostate Cancer is Associated with Rapid Disease Progression

  Dac EGAC00001001718

• DAC for Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancer

  Dac EGAC00001002644

• EGAD00010000570

  Imputation-based meta-analysis of severe malaria in Kenya.

  Dataset EGAD00010000570

• Landscape of gene mutations in Down syndrome-related myeloid disorders

  Dataset EGAD00001000628

• RHD_FJ_OMNI_Controls

  Healthy volunteers recruited in Fiji with higher density genotyping

  Dataset EGAD00010000958

• Recurrent adeno-associated virus 2-related insertional mutagenesis in human hepatocellular carcinomas

  Dataset EGAD00001001423

• Molecular Classification of Lymph Node Metastases Subtypes Predict for Survival in Head and Neck Cancer

  Study EGAS00001003233

• T cell receptors of pathogenic CD4 T cells isolated by using distinct phenotypic markers in celiac disease

  Study EGAS00001005582

• Increased trunk fat is associated with altered gene expression in breast tissue of normal weight women

  Study EGAS00001005138

• Molecular analysis of CRC in patients with Primary Sclerosing Cholangitis (PSC) and Inflammatory Bowel Disease (IBD)

  Study EGAS00001004497

• Impaired Humoral and Cellular Immunity after SARS-CoV2 BNT162b2 (Tozinameran) Prime-Boost Vaccination in Kidney Transplant Recipients

  Study EGAS00001005280

• Identification of early disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis (hipo_K34R)

  Study EGAS00001005327

• Mutational impact in liver stem cells under precancerous alcoholic liver, NASH and PSC disease conditions

  Study EGAS00001005384

• Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer

  Study EGAS00001005967

• Mitochondrial variants in CPCGene samples

  VCF files containing mitochondrial variant calls using MToolbox

  Dataset EGAD00001003361

• Whole genome sequencing of preneoplasia lung adenocarcinoma

  Whole genome sequencing of 42 pulmonary samples including lung preneoplasia atypical adenomatous hyperplasia (AAH, N=5), adenocarcinoma in situ (AIS, N=7), minimally invasive adenocarcinoma (MIA, N=6) and invasive lung adenocarcinoma (ADC, N=8) and adjacent lung tissues (Normal, N=16).

  Study EGAS50000000272

• Hi-C analysis of patient-derived pancreas neoplasm organoids

  Pancreatic cancers arise from two different precursors; intraductal papillary mucinous neoplasms (IPMN) and pancreatic intraepithelial neoplasm (PanIN), while biological differences in cancers originated from thme remain obscure. Here, we analyzed their three-dimensional genome structure by Hi-C using patient-derived organoids.

  Study JGAS000262

• ChIP-Seq on multiple myeloma and plasma cell leukaemia cell lines

  ChIP-seq data (H3K4Me1, H3K4Me3, H3K27Ac histone modifications) in experimental triplicates on multiple myeloma cell line KMS11 and plasma cell leukaemia cell lines L363 and JJN3. ChIP reactions were performed on a Diagenode SX-8G IP-Star Compact using Diagenode automated Ideal Kit. ChIP libraries were generated using HTP Illumina library preparation kit, and sequenced using Illumina HiSeq 2000 with 100 bp single-ended reads. ChIP-seq files are in BED format.

  Dataset EGAD00001003349

• Genomic and clinical data from IMmotion010, a phase 3 randomised clinical trial testing adjuvant atezolizumab versus placebo for patients with renal cell carcinoma at increased risk of recurrence following resection

  778 patients were randomized in this study. Pre-treatment bulk RNAseq of primary tumors was conducted for 754 patients. For 80 patients, bulk RNAseq analysis of a metastastic biopsy was conducted. For these 80 pairs, DNA alterations were assessed in pre-treatment and at recurrence using FoundationOne.

  Dataset EGAD50000001827

• usgwas-QC_imputed_update

  Understanding Society GWAS, samples that passed quality control, imputed to UK10K + 1000 Genomes combined reference panel

  Dataset EGAD00010000918

• A novel orthotopic patient-derived xenograft model of radiation-induced glioma following medulloblastoma

  DNA methylation arrays were performed to molecularly subtype these samples based on Capper D, Jones DTW, Sill M, et al. DNA methylation-based classification of central nervous system tumours. Nature. 2018;555(7697):469-474. doi:10.1038/nature26000

  Dataset EGAD00010002017

• Human TRIM24-MET fusion HGG RNA-seq

  Human RNA-seq data for TRIM24-MET fusion tumor primary samples and patient/PDOX-derived cell lines. Cells were treated with 0.1% DMSO or EC90 of MET inhibitors (capmatinib, cabozantinib, crizotinib) for 4 hours. BAM files containing aligned (and unaligned) reads to hg19 are provided.

  Dataset EGAD50000000194

• cfDNA sWGS BAM — NSCLC stage I–III

  Plasma cfDNA sWGS for NSCLC patients (stage I–III), blood drawn pre-operatively, CHU Montpellier/LUNGDOC study. Libraries: DSP as recorded. Sequencing provider IntegraGen (2022–2024). Alignment to GRCh38 (hg38 canonical), BWA-MEM; BAMs sorted/indexed; only primary mapped reads retained (analysis pages list -F/MAPQ). Controlled access.

  Dataset EGAD50000001878

• Exome Sequencing data from infertility cases.

  This dataset includes exome sequencing (ES) from a cohort of patients with infertility. Sequencing was performed on genomic DNA extracted from blood, using Agilent SureSelect XT Low Input exome capture and Illumina NovaSeq 6000 paired-end sequencing and is intended to facilitate research into novel genetic causes of infertility.

  Dataset EGAD50000001881

• Dataset of Recurrent resistance mutations to lirafugratinib delineate treatment sequences for FGFR2-driven tumors

  This dataset is made of 23 pairs of RNAseq and 36 pairs of Exome-seq, both sequenced from Illumina Novaseq. This includes 47 samples, composed of 25 tumors, 13 healthy and 9 xenograft

  Dataset EGAD50000001981

• WGS of all Patients Listed within this Study

  This dataset contains WGS from whole blood of patients II.2, II.3, III.1-4 and WGS from fibroblasts of patients III.2 and III.3. All WGS was performed on an Illumina NextSeq2000 to a minimum depth of 250 million read pairs (2x150nts).

  Dataset EGAD50000002362

• Untargeted serum metabolomics profiled by Metabolon Inc.

  Raw untargeted metabolomics profiled by Metabolon Inc. for 540 samples from healthy individuals. Files include sample names and run details which can be matched to their metagenomic sequencing samples from PRJEB11532 and PRJEB17643. Information regarding metabolite metadata is also available, including

  Dataset EGAD00001006247

• WES CRAM files of HUG-CEL Covid-19 Genomics Study

  Whole Exome Sequencing Dataset (CRAM files) of 415 admixed Brazilians with Covid-19 extreme phenotypes from recovered nonagenarians and centenarians to deceased adults.

  Dataset EGAD00001009652

• Colonbiome shot-gun metagenomics

  156 samples of shot-gun gut metagenomics, corresponding to 51 patients with CRCm 54 patients with adenoma, and 51 healthy controls

  Dataset EGAD00001010068

• ICR_RNASeq_pHGG

  RNA sequencing of paediatric high grade gliomas and diffuse intrinsic pontine gliomas. RNA was sequenced from fresh frozen surgical material or from primary cells cultured under stem cell conditions. RNA was subjected to Illumina whole transcriptome paired end sequencing. Data is provided as paired-end FASTQ files

  Dataset EGAD00001004116

• Single-cell Transcriptome for glioblastoma intra-tumoral heterogeneity

  Single-Cell RNA Sequencing of 355 cells isolated from 7 tissue fragments of 3 patients corresponding to locally adjacent tumor, multifocal with recurrence and sections segregated by a marker of tumor cellularity (5-ALA).

  Dataset EGAD00001002249

• Clinical exome profiling of 7 members of a family with cases of familial Alzheimer's disease

  This dataset includes "clinical exome" profiling (approximately 4000 genes related to diseases) on individuals (n=7) from a family with a familial history of Alzheimer's disease. Two affected cases ad five cases without dementia are included.

  Dataset EGAD00001005320

• Targeted resequencing of coding regions of ribosomal protein genes in multiple myeloma samples

  Dataset EGAD00001003302

• Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma

  Study EGAS00001004430

• Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard and high risk myeloma

  Study EGAS00001004558

• ATM germline variants in a young adult with chronic lymphocytic leukemia: 8 years of genomic evolution

  Study EGAS00001006268

• Genetic drivers define transcriptomic characteristics and clonal hierarchy within intratumoral heterogeneity in adult T-cell leukemia-lymphoma

  Study JGAS000301

• Transcriptional and DNA binding profiling of CEBPE in REH acute lymphoblastic leukaemia cells using shRNA RNA-Seq and ChIP-Seq

  Dac EGAC00001000891

• Data access committee for white blood cell and cell-free DNA analyses for detection of residual disease in gastric cancer

  Dac EGAC00001001435

• Data Access Commitee for study Fine-Scale Genomic Analyses Of Admixed Individuals Reveal Unrecognized Genetic Ancestry Components In Argentina

  Dac EGAC00001001634

• Data Access Commitee - Monocyte and macrophage lipid accumulation results in downregulated type-I interferon responses - FH monocytes RNA sequencing data

  Dac EGAC00001002495

• OGVP_HC24_Controls

  Healthy adult volunteers and newborns recruited in various countries across Oceania.

  Dataset EGAD00010000953

• RHD_FJ_OMNI_Cases

  Rheumatic heart disease cases recruited in Fiji with higher density genotyping

  Dataset EGAD00010000955

• Time series analysis of neoadjuvant chemotherapy and bevacizumab treated breast carcinomas reveals a systemic shift in genomic aberrations

  Study EGAS00001003287

• TallFlow: Lineage tracing of immunophenotypic sub populations in T-cell Acute lymphoblastic leukemia by (sc-)WGS

  Study EGAS00001007446

• Small molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma (RNAseq dataset)

  Study EGAS00001004748

• CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas

  Study EGAS00001007577

• Single cell characterization of arrested B-lymphoid differentiation and leukemic cell states in ETV6-RUNX1-positive pediatric leukemia

  Study EGAS00001004374

• Longitudinal monitoring of disease burden and response using ctDNA from dried blood spots in xenograft models

  Study EGAS00001006134

• Complex patterns of genomic heterogeneity identified in 42 tumor samples and ctDNA of a pulmonary atypical carcinoid patient

  Study EGAS00001006530

• Patient-derived organoids identify tailored therapeutic options and determinants of plasticity in sarcomatoid urothelial bladder cancer

  Study EGAS00001007430

• Therapeutic vulnerabilities in CCA from different etiologies identified using integrative multi-omics enhancer activity profiling

  Study EGAS00001007309

• Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

  Study EGAS00001005599